Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Abstract Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the formation of large tissue destructive lesio...

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Main Authors: Irina Tsymala, Magdalini Nigritinou, Bleranda Zeka, Rouven Schulz, Felix Niederschick, Mia Matković, Isabel J. Bauer, Michael Szalay, Kathrin Schanda, Magdalena Lerch, Tatsuro Misu, Kazuo Fujihara, Jeffrey L. Bennett, Charlotte Dahle, Florence Pache, Paulus Rommer, Fritz Leutmezer, Zsolt Illes, Maria Isabel Leite, Jacqueline Palace, Petra Scholze, Markus Reindl, Hans Lassmann, Monika Bradl
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Neuromyelitis optica spectrum disorders
Antibodies
Mimotopes
Aquaporin 4
Infections
Animal model
Online Access:http://link.springer.com/article/10.1186/s40478-020-00920-x

Internet

http://link.springer.com/article/10.1186/s40478-020-00920-x

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