PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy

PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy

Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing immune responses. Here we show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs. Mice with conditional knock out (cKO) of PRMT5 expression in Tregs de...

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Bibliographic Details
Main Authors: Yasuhiro Nagai, Mei Q. Ji, Fuxiang Zhu, Yan Xiao, Yukinori Tanaka, Taku Kambayashi, Shigeyoshi Fujimoto, Michael M. Goldberg, Hongtao Zhang, Bin Li, Takuya Ohtani, Mark I. Greene
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
PRMT5
FOXP3 regulatory T cells
autoimmunity
scurfy
tumor immunity
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00174/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00174/full

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