Bivalent genes that undergo transcriptional switching identify networks of key regulators of embryonic stem cell differentiation

Bivalent genes that undergo transcriptional switching identify networks of key regulators of embryonic stem cell differentiation

Abstract Background Bivalent promoters marked with both H3K27me3 and H3K4me3 histone modifications are characteristic of poised promoters in embryonic stem (ES) cells. The model of poised promoters postulates that bivalent chromatin in ES cells is resolved to monovalency upon differntiation. With th...

Full description

Bibliographic Details
Main Authors: Ah-Jung Jeon, Greg Tucker-Kellogg
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Genomics
Subjects:
Bivalency
Embryonic stem cells
scRNA-seq
Bimodality
Chromatin state
Pseudotime
Online Access:http://link.springer.com/article/10.1186/s12864-020-07009-8

Internet

http://link.springer.com/article/10.1186/s12864-020-07009-8

Similar Items