Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia

Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia

<b>: </b>Protein tyrosine phosphatase receptor type &#947; (PTPRG) is a tumor suppressor gene, down-regulated in Chronic Myeloid Leukemia (CML) cells by the hypermethylation of its promoter region. &#946;-catenin (CTNNB1) is a critical regulator of Leukemic Stem Cells (LSC) maint...

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Bibliographic Details
Main Authors: Luisa Tomasello, Marzia Vezzalini, Christian Boni, Massimiliano Bonifacio, Luigi Scaffidi, Mohamed Yassin, Nader Al-Dewik, Paul Takam Kamga, Mauro Krampera, Claudio Sorio
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
β-catenin
ptprg
chronic myeloid leukemia
methylation
tumor suppressor
tyrosine phosphatase
dnmt
5-azacytidine
Online Access:https://www.mdpi.com/1422-0067/21/7/2298

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https://www.mdpi.com/1422-0067/21/7/2298

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