Establishment and Application of a High Throughput Screening System Targeting the Interaction between HCV Internal Ribosome Entry Site and Human Eukaryotic Translation Initiation Factor 3

Establishment and Application of a High Throughput Screening System Targeting the Interaction between HCV Internal Ribosome Entry Site and Human Eukaryotic Translation Initiation Factor 3

Viruses are intracellular obligate parasites and the host cellular machinery is usually recruited for their replication. Human eukaryotic translation initiation factor 3 (eIF3) could be directly recruited by the hepatitis C virus (HCV) internal ribosome entry site (IRES) to promote the translation o...

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Bibliographic Details
Main Authors: Yuying Zhu, Pei Huang, Na Yang, Rui Liu, Xueting Liu, Huanqin Dai, Lixin Zhang, Fuhang Song, Chaomin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
hepatitis C virus
IRES
eIF3
high throughput
enhancer
inhibitor
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00977/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00977/full

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