Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics

Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics

Abstract Single‐cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging. Here, we generate independent single‐cell RNA‐seq and single‐cell ATAC‐seq atlase...

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Bibliographic Details
Main Authors: Carmen Bravo González‐Blas, Xiao‐Jiang Quan, Ramon Duran‐Romaña, Ibrahim Ihsan Taskiran, Duygu Koldere, Kristofer Davie, Valerie Christiaens, Samira Makhzami, Gert Hulselmans, Maxime deWaegeneer, David Mauduit, Suresh Poovathingal, Sara Aibar, Stein Aerts
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Molecular Systems Biology
Subjects:
enhancer detection
eye‐antennal disc
gene regulation
single‐cell omics
spatial integration
Online Access:https://doi.org/10.15252/msb.20209438

Internet

https://doi.org/10.15252/msb.20209438

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