Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages

Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages

Background: Based on reports on elevated cholesterol levels in cancer cells, strategies to lower cholesterol synthesis have been suggested as an antitumour strategy. However, cholesterol depletion has also been shown to induce tumour-promoting actions in tumour-associated macrophages (TAMs). Methods...

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Bibliographic Details
Main Authors: Jessica Hoppstädter, Anna Dembek, Marcus Höring, Hanna S. Schymik, Charlotte Dahlem, Afnan Sultan, Natalie Wirth, Salma Al-Fityan, Britta Diesel, Gilles Gasparoni, Jörn Walter, Volkhard Helms, Hanno Huwer, Martin Simon, Gerhard Liebisch, Marcel H. Schulz, Alexandra K. Kiemer
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:EBioMedicine
Subjects:
Non-small cell lung cancer
innate immune response
ABCA1
ABCG1
ATR-101
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003716

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http://www.sciencedirect.com/science/article/pii/S2352396421003716

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