Eicosapentaenoic Acid Inhibits <i>KRAS</i> Mutant PancreaticCancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation

Eicosapentaenoic Acid Inhibits <i>KRAS</i> Mutant PancreaticCancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation

Background: The oncogenic Kirsten rat sarcoma viral oncogene homolog (<i>KRAS</i>) mutation was reported to be the signature genetic event in most cases of pancreatic ductal adenocarcinoma (PDAC). Hepassocin (HPS/FGL1) is involved in regulating lipid metabolism and the progression of sev...

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Bibliographic Details
Main Authors: Ching-Feng Chiu, Ming-I Hsu, Hsiu-Yen Yeh, Ji Min Park, Yu-Shiuan Shen, Te-Hsuan Tung, Jun-Jie Huang, Hung-Tsung Wu, Shih-Yi Huang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
pancreatic cancer
<i>KRAS</i> mutation
hepassocin
eicosapentaenoic acid
Online Access:https://www.mdpi.com/2218-273X/11/3/370

Internet

https://www.mdpi.com/2218-273X/11/3/370

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