Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

Objectives: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1, but littl...

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Bibliographic Details
Main Authors: Scott A. Campbell, Dominic P. Golec, Matt Hubert, Janyne Johnson, Nicole Salamon, Amy Barr, Patrick E. MacDonald, Koenraad Philippaert, Peter E. Light
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Metabolism
Subjects:
Human islets
Glucagon-like peptide-1
GLP-1
Glucagon
Alpha-cell
Beta-cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300880

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http://www.sciencedirect.com/science/article/pii/S2212877820300880

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