Lestaurtinib inhibition of the Jak/STAT signaling pathway in hodgkin lymphoma inhibits proliferation and induces apoptosis.

Lestaurtinib inhibition of the Jak/STAT signaling pathway in hodgkin lymphoma inhibits proliferation and induces apoptosis.

Standard cytotoxic chemotherapy for Hodgkin Lymphoma (HL) has changed little in 30 years; the treatment for patients with relapsed or refractory disease remains challenging and novel agents are under development. JAK/STAT constitutive activation plays an important role in the pathogenesis of HL. Les...

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Bibliographic Details
Main Authors: Tania Diaz, Alfons Navarro, Gerardo Ferrer, Bernat Gel, Anna Gaya, Rosa Artells, Beatriz Bellosillo, Mar Garcia-Garcia, Sergi Serrano, Antonio Martínez, Mariano Monzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3080386?pdf=render

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http://europepmc.org/articles/PMC3080386?pdf=render

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