Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage.

Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage.

Actin, one of the most evolutionarily conservative proteins in eukaryotes, is distributed both in the cytoplasm and the nucleus, and its dynamics plays important roles in numerous cellular processes. Previous evidence has shown that actin interacts with p53 and this interaction increases in the proc...

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Bibliographic Details
Main Authors: Ling Wang, Min Wang, Shuyan Wang, Tianyang Qi, Lijing Guo, Jinjiao Li, Wenjing Qi, Khamal Kwesi Ampah, Xueqing Ba, Xianlu Zeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3615075?pdf=render

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http://europepmc.org/articles/PMC3615075?pdf=render

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