Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation

Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation

Aims:<b> </b>Anti-Apolipoprotein A-1 autoantibodies (anti-ApoA-1 IgG) promote atherogenesis via innate immune receptors, and may impair cellular cholesterol homeostasis (CH). We explored the presence of anti-ApoA-1 IgG in children (5&#8722;15 years old) with or without familial hyper...

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Bibliographic Details
Main Authors: Sabrina Pagano, Alessandra Magenta, Marco D’Agostino, Francesco Martino, Francesco Barillà, Nathalie Satta, Miguel A. Frias, Annalisa Ronca, François Mach, Baris Gencer, Elda Favari, Nicolas Vuilleumier
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Journal of Clinical Medicine
Subjects:
anti-apolipoprotein a-1 igg
familial hypercholesterolemia
cholesterol homeostasis
foam cells
mir-33a
tlr2/4
passive diffusion
Online Access:https://www.mdpi.com/2077-0383/8/12/2035

Internet

https://www.mdpi.com/2077-0383/8/12/2035

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