Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF‐1α/VEGF pathway in traumatic brain injury

Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF‐1α/VEGF pathway in traumatic brain injury

Abstract Objective Traumatic brain injury (TBI) results not only in gray matter damage, but also in severe white matter injury (WMI). Previous findings support hypoxic preconditioning (HP) could augment the efficacy of bone marrow stromal cell (BMSC) transplantation in a TBI mouse model. However, wh...

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Bibliographic Details
Main Authors: Xiaoyu Yuan, Qianqian Luo, Lihua Shen, Jin Chen, Deqiang Gan, Yechao Sun, Lingzhi Ding, Guohua Wang
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Brain and Behavior
Subjects:
bone marrow stromal cells
hypoxic preconditioning
oligodendrogenesis
remyelination
traumatic brain injury
Online Access:https://doi.org/10.1002/brb3.1675

Internet

https://doi.org/10.1002/brb3.1675

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