Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. I...

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Bibliographic Details
Main Authors: Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Ting Deng, Rui Liu, Qian Fan, Kegan Zhu, Jialu Li, Yang Zhan, Guoguang Ying, Yi Ba
Format: Article
Published: Wiley 2020-03-01
Series:Molecular Oncology
Online Access:https://doi.org/10.1002/1878-0261.12629