Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors, and Efficacy in Animal Models of Depression

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors, and Efficacy in Animal Models of Depression

New compounds with a 7-amino-2-arylmethyl-thiazolo[5,4-d]pyrimidine structure were synthesized and evaluated in vitro for their affinity and/or potency at the human (h) A<sub>1</sub>, hA<sub>2A</sub>, hA<sub>2B</sub>, and hA<sub>3</sub> adenosine recep...

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Bibliographic Details
Main Authors: Flavia Varano, Daniela Catarzi, Erica Vigiani, Diego Dal Ben, Michela Buccioni, Gabriella Marucci, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carla Ghelardini, Rosaria Volpini, Vittoria Colotta
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
G protein-coupled receptors
adenosine A<sub>1</sub> receptor ligands
adenosine A<sub>2A</sub> receptor ligands
thiazolo[5,4-d]pyrimidines
ligand-adenosine receptor modeling studies
depression
Online Access:https://www.mdpi.com/1424-8247/14/7/657

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https://www.mdpi.com/1424-8247/14/7/657

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