Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

Abstract Background Recent large-scale clinical trials have shown that SGLT2-inhibitors reduce cardiovascular events in diabetic patients. However, the regulation and functional role of cardiac sodium–glucose cotransporter (SGLT1 is the dominant isoform) compared with those of other glucose transpor...

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Bibliographic Details
Main Authors: Akira Yoshii, Tomohisa Nagoshi, Yusuke Kashiwagi, Haruka Kimura, Yoshiro Tanaka, Yuhei Oi, Keiichi Ito, Takuya Yoshino, Toshikazu D. Tanaka, Michihiro Yoshimura
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cardiovascular Diabetology
Subjects:
SGLT1
Phlorizin
SGLT2-inhibitor
GLUT4
Insulin resistance
Ischemia–reperfusion injury
Online Access:http://link.springer.com/article/10.1186/s12933-019-0889-y

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http://link.springer.com/article/10.1186/s12933-019-0889-y

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