Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo

Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo

The chemotherapeutic agent temozolomide (TMZ) kills tumor cells preferentially via alkylation of the O6-position of guanine. However, cells that express the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), or harbor deficient DNA mismatch repair (MMR) function, are profoundly resista...

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Bibliographic Details
Main Authors: Thomas C. Chen, Nymph Chan, Radu O. Minea, Hannah Hartman, Florence M. Hofman, Axel H. Schönthal
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
O6-methylguanine-DNA methyltransferase
MGMT
chemoresistance
Online Access:http://www.mdpi.com/2072-6694/10/10/362

Internet

http://www.mdpi.com/2072-6694/10/10/362

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