c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.

Bibliographic Details
Main Authors: Yu Chen Feng, Xiao Ying Liu, Liu Teng, Qiang Ji, Yongyan Wu, Jin Ming Li, Wei Gao, Yuan Yuan Zhang, Ting La, Hessam Tabatabaee, Xu Guang Yan, M. Fairuz B. Jamaluddin, Didi Zhang, Su Tang Guo, Rodney J. Scott, Tao Liu, Rick F. Thorne, Xu Dong Zhang, Lei Jin
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18735-8

Internet

https://doi.org/10.1038/s41467-020-18735-8

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