De novo design of a homo-trimeric amantadine-binding protein

De novo design of a homo-trimeric amantadine-binding protein

The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved. We used de novo protein design to create a homo-trimeric protein that binds the C3 symmetric small molecule drug amantadine with each protein...

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Bibliographic Details
Main Authors: Jooyoung Park, Brinda Selvaraj, Andrew C McShan, Scott E Boyken, Kathy Y Wei, Gustav Oberdorfer, William DeGrado, Nikolaos G Sgourakis, Matthew J Cuneo, Dean AA Myles, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
de novo protein design
symmetry
amantadine
Rosetta
Online Access:https://elifesciences.org/articles/47839

Internet

https://elifesciences.org/articles/47839

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