Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives

Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives

Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-cryst...

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Bibliographic Details
Main Authors: Jiri Dohnal, Josef Jampílek, Lukas Placek, Marcela Tkadlecova, Anna Rezacova, Jaroslav Havlicek, Lenka Havelkova, Zbynek Oktabec, Jiri Kos, Zuzana Mandelova, Tomas Pekarek
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
ibandronate
d-glucopyranosides
d-galactopyranosides
co-crystals
FT-NIR
FT-Raman
CP/MAS NMR
PAMPA
Online Access:http://www.mdpi.com/1420-3049/15/12/8973/

Internet

http://www.mdpi.com/1420-3049/15/12/8973/

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