A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism.

A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism.

The ABO locus in humans is characterized by elevated heterozygosity and very similar allele frequencies among populations scattered across the globe. Using knowledge of ABO protein function, we generated a simple model of asymmetric negative frequency dependent selection and genetic drift to explain...

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Bibliographic Details
Main Authors: Fernando A Villanea, Kristin N Safi, Jeremiah W Busch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4422588?pdf=render

Internet

http://europepmc.org/articles/PMC4422588?pdf=render

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