Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration of retinal ganglion c...

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Bibliographic Details
Main Authors: Henry T. Hsueh, Yoo-Chun Kim, Ian Pitha, Matthew D. Shin, Cynthia A. Berlinicke, Renee Ti Chou, Elizabeth Kimball, Julie Schaub, Sarah Quillen, Kirby T. Leo, Hyounkoo Han, Amy Xiao, Youngwook Kim, Matthew Appell, Usha Rai, HyeYoung Kwon, Patricia Kolodziejski, Laolu Ogunnaike, Nicole M. Anders, Avelina Hemingway, Joan L. Jefferys, Abhijit A. Date, Charles Eberhart, Thomas V. Johnson, Harry A. Quigley, Donald J. Zack, Justin Hanes, Laura M. Ensign
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
neuroprotection
tyrosine kinase inhibitor
ocular drug delivery
pamoic acid
sunitinib
glaucoma
Online Access:https://www.mdpi.com/1999-4923/13/5/647

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https://www.mdpi.com/1999-4923/13/5/647

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