Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive regulator of microtubule polymerization and sta...

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Bibliographic Details
Main Authors: Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cytoskeleton
Crmp2
microtubules
neurite
neurodevelopment
neuronal polarity
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00124/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00124/full

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