Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With MacrophagesSummary

Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With MacrophagesSummary

Background & Aims: Cancer-associated fibroblasts (CAFs) from pancreatic adenocarcinoma (PDA) present high protein synthesis rates. CAFs express the G-protein–coupled somatostatin receptor sst1. The sst1 agonist SOM230 blocks CAF protumoral features in vitro and in immunocompromised mice. We...

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Bibliographic Details
Main Authors: Rémi Samain, Alexia Brunel, Thibault Douché, Marjorie Fanjul, Stéphanie Cassant-Sourdy, Julia Rochotte, Jérôme Cros, Cindy Neuzillet, Jérôme Raffenne, Camille Duluc, Aurélie Perraud, Jérémy Nigri, Véronique Gigoux, Ivan Bieche, Matteo Ponzo, Gilles Carpentier, Ilaria Cascone, Richard Tomasini, Herbert A. Schmid, Muriel Mathonnet, Rémy Nicolle, Marie-Pierre Bousquet, Yvan Martineau, Stéphane Pyronnet, Christine Jean, Corinne Bousquet
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Antimetastatic Therapy
Cancer-Associated Fibroblasts
Pancreatic Adenocarcinoma
Stromal Cell Cross-Talk
Stroma Normalization
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2100014X

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http://www.sciencedirect.com/science/article/pii/S2352345X2100014X

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