Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses we...

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Bibliographic Details
Main Authors: Robert A Benson, Megan KL MacLeod, Benjamin G Hale, Agapitos Patakas, Paul Garside, James M Brewer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/06994