A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

Epilepsy is a disorder characterized by seizures and convulsions. The basis of epilepsy is an increase in neuronal excitability that, in some cases, may be caused by functional defects in neuronal voltage gated sodium channels (NaVs). The C121W mutation of the β1 subunit, in particular, gives rise t...

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Bibliographic Details
Main Authors: Mena eAbdelsayed, Stanislav eSokolov, Peter eRuben
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Pharmacology
Subjects:
Slow inactivation
voltage-gated sodium channels
lacosamide
GEFS+
thermosensitive
WT-β1 (wild-type)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00121/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00121/full

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