Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

Sumoylation is a downstream effector of aging/oxidative stress; excess oxidative stress leads to dysregulation of a specificity protein1 (Sp1) and its target genes, such as Peroxiredoxin 6 (Prdx6), resulting in cellular damage. To cope with oxidative stress, cells rely on a signaling pathway involvi...

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Bibliographic Details
Main Authors: Bhavana Chhunchha, Prerna Singh, Dhirendra P. Singh, Eri Kubo
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
Sumo1
ginkgolic acid
betulinic acid
Prdx6
Sp1
Online Access:https://www.mdpi.com/1422-0067/19/11/3520

Internet

https://www.mdpi.com/1422-0067/19/11/3520

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