Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem cells (mESCs) with varying DNA methylation levels...

Full description

Bibliographic Details
Main Authors: Andrew D. King, Kevin Huang, Liudmilla Rubbi, Shuo Liu, Cun-Yu Wang, Yinsheng Wang, Matteo Pellegrini, Guoping Fan
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
DNA methylation
histone modifications
chromatin
polycomb
embryonic stem cells
enhancers
promoters
gene regulation
epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311792

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716311792

Similar Items