Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease

Abstract Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs...

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Bibliographic Details
Main Authors: Chin-Hsien Lin, K. Ray Chaudhuri, Jun-Yu Fan, Chia-I. Ko, Alexandra Rizos, Chia-Wen Chang, Han-I. Lin, Yih-Ru Wu
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06782-z