An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells

An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells

Selectively depleting the pathogenic T cells is a fundamental strategy for the treatment of allograft rejection and autoimmune disease since it retains the overall immune function of host. The concept of killer artificial antigen-presenting cells (KaAPCs) has been developed by co-coupling peptide–ma...

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Bibliographic Details
Main Authors: Wei Wang, Khawar Ali Shahzad, Miaochen Li, Aifeng Zhang, Lei Zhang, Tao Xu, Xin Wan, Chuanlai Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
biomimetic microparticle
poly lactic-co-glycolic acid
peptide–major histocompatibility complex
alloreactive T cells
allograft rejection
killer artificial antigen-presenting cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00657/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00657/full

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