Genotoxic Bystander Signals from Irradiated Human Mesenchymal Stromal Cells Mainly Localize in the 10–100 kDa Fraction of Conditioned Medium

Genotoxic Bystander Signals from Irradiated Human Mesenchymal Stromal Cells Mainly Localize in the 10–100 kDa Fraction of Conditioned Medium

Genotoxic bystander signals released from irradiated human mesenchymal stromal cells (MSC) may induce radiation-induced bystander effects (RIBEs) in human hematopoietic stem and progenitor cells (HSPC), potentially causing leukemic transformation. Although the source of bystander signals is evident,...

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Bibliographic Details
Main Authors: Vanessa Kohl, Alice Fabarius, Oliver Drews, Miriam Bierbaum, Ahmed Jawhar, Ali Darwich, Christel Weiss, Johanna Flach, Susanne Brendel, Helga Kleiner, Wolfgang Seifarth, Wolf-Karsten Hofmann, Henning D. Popp
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
bystander signals
radiation-induced bystander effects
mesenchymal stromal cells
CD34+ cells
leukemia
Online Access:https://www.mdpi.com/2073-4409/10/4/827

Internet

https://www.mdpi.com/2073-4409/10/4/827

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