Structural characterization of free-state and product-state Mycobacterium tuberculosis methionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism

Structural characterization of free-state and product-state Mycobacterium tuberculosis methionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism

Mycobacterium tuberculosis (MTB) caused 10.4 million cases of tuberculosis and 1.7 million deaths in 2016. The incidence of multidrug-resistant and extensively drug-resistant MTB is becoming an increasing threat to public health and the development of novel anti-MTB drugs is urgently needed. Methion...

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Bibliographic Details
Main Authors: Wei Wang, Bo Qin, Justyna Aleksandra Wojdyla, Meitian Wang, Xiaopan Gao, Sheng Cui
Format: Article
Language:English
Published: International Union of Crystallography 2018-07-01
Series:IUCrJ
Subjects:
Mycobacterium tuberculosis
methionyl-tRNA synthetase
crystal structure
induced fit
antituberculosis drugs
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252518008217

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http://scripts.iucr.org/cgi-bin/paper?S2052252518008217

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