Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA. We created D6D-null mice (−/−), which enabled us to st...

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Bibliographic Details
Main Authors: Chad K. Stroud, Takayuki Y. Nara, Manuel Roqueta-Rivera, Emily C. Radlowski, Peter Lawrence, Ying Zhang, Byung H. Cho, Mariangela Segre, Rex A. Hess, J. Thomas Brenna, Wanda M. Haschek, Manabu T. Nakamura
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
delta-6 desaturase
docosahexaenoic acid
docosapentaenoic acid
eicosanoid
essential fatty acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307392

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http://www.sciencedirect.com/science/article/pii/S0022227520307392

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