Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque

Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque

ObjectivesAnti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established. The main genetic risk factor for RA, the shared epitope in major histocompatibility complex class II, is asso...

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Bibliographic Details
Main Authors: Samuel Bitoun, Pierre Roques, Thibaut Larcher, Gaétane Nocturne, Che Serguera, Pascale Chrétien, Guy Serre, Roger Le Grand, Xavier Mariette
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
ACPA
neutrophils
citrulline
shared epitope
macaque
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01816/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01816/full

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