Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
The ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in huma...
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doaj-325f3f4ba945488c9899ec7825f261782021-03-22T14:39:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-03-011510.3389/fnins.2021.654176654176Quantitative Methods for the Detection of Tau Seeding Activity in Human BiofluidsAurelien Lathuiliere0Aurelien Lathuiliere1Bradley T. Hyman2Bradley T. Hyman3Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, United StatesHarvard Medical School, Boston, MA, United StatesAlzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, United StatesHarvard Medical School, Boston, MA, United StatesThe ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in human samples may be relevant and correlate with clinical data. Here, we review the available methods for the measurement of such tau seeds, their limitations and their potential implementation for the development of the next-generation biomarkers.https://www.frontiersin.org/articles/10.3389/fnins.2021.654176/fulltauseedbiomarkerAlzheimer’s diseasecerebrospinal fluid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aurelien Lathuiliere Aurelien Lathuiliere Bradley T. Hyman Bradley T. Hyman |
spellingShingle |
Aurelien Lathuiliere Aurelien Lathuiliere Bradley T. Hyman Bradley T. Hyman Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids Frontiers in Neuroscience tau seed biomarker Alzheimer’s disease cerebrospinal fluid |
author_facet |
Aurelien Lathuiliere Aurelien Lathuiliere Bradley T. Hyman Bradley T. Hyman |
author_sort |
Aurelien Lathuiliere |
title |
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids |
title_short |
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids |
title_full |
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids |
title_fullStr |
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids |
title_full_unstemmed |
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids |
title_sort |
quantitative methods for the detection of tau seeding activity in human biofluids |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2021-03-01 |
description |
The ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in Alzheimer’s disease (AD) and other tauopathies. Recent evidence suggests that the detection of tau seeds in human samples may be relevant and correlate with clinical data. Here, we review the available methods for the measurement of such tau seeds, their limitations and their potential implementation for the development of the next-generation biomarkers. |
topic |
tau seed biomarker Alzheimer’s disease cerebrospinal fluid |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2021.654176/full |
work_keys_str_mv |
AT aurelienlathuiliere quantitativemethodsforthedetectionoftauseedingactivityinhumanbiofluids AT aurelienlathuiliere quantitativemethodsforthedetectionoftauseedingactivityinhumanbiofluids AT bradleythyman quantitativemethodsforthedetectionoftauseedingactivityinhumanbiofluids AT bradleythyman quantitativemethodsforthedetectionoftauseedingactivityinhumanbiofluids |
_version_ |
1724207208130936832 |