Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2′, 3′-cGAMP VacciGrade™ adjuvant exacerbates viremia after virus challenge

Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2′, 3′-cGAMP VacciGrade™ adjuvant exacerbates viremia after virus challenge

Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failure in pregnant sows and acute respiratory disease in young pigs. It is a leading infectious agent of swine respiratory complex, which has significant negative economic impact on the swine industr...

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Bibliographic Details
Main Authors: Alexandria Van Noort, April Nelsen, Angela E. Pillatzki, Diego G. Diel, Feng Li, Eric Nelson, Xiuqing Wang
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Virology Journal
Subjects:
2′, 3′-cGAMP vaccigrade™
PRRSV
Virus-like particles
Increased viremia
Intranasal immunization
Interferon-α
Online Access:http://link.springer.com/article/10.1186/s12985-017-0746-0

Internet

http://link.springer.com/article/10.1186/s12985-017-0746-0

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