TOX as a potential target for immunotherapy in lymphocytic malignancies

TOX as a potential target for immunotherapy in lymphocytic malignancies

Abstract TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this revie...

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Bibliographic Details
Main Authors: Chaofeng Liang, Shuxin Huang, Yujie Zhao, Shaohua Chen, Yangqiu Li
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Biomarker Research
Subjects:
Thymocyte selection-associated HMG BOX
Biological function
T cell exhaustion
Lymphocytic malignancies
Immune biomarker
Immunotherapy
Online Access:https://doi.org/10.1186/s40364-021-00275-y

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