Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model

Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model

Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratumoral cells, making them highly appropriate therap...

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Bibliographic Details
Main Authors: Jennifer Williams, Gary Shaw, Tereza Andreou, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Heiko Wurdak, Susan C Short, Mihaela Lorger
Format: Article
Language:English
Published: BMJ Publishing Group 2021-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/3/e001143.full

Internet

https://jitc.bmj.com/content/9/3/e001143.full

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