A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies <em>COL22A1</em> as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies <em>COL22A1</em> as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition

<b>: </b>Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do not fully recapitulate the hu...

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Bibliographic Details
Main Authors: Tomoya Watanabe, DeAnna Baker Frost, Logan Mlakar, Jonathan Heywood, Willian A. da Silveira, Gary Hardiman, Carol Feghali-Bostwick
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Genes
Subjects:
fibrosis
systemic sclerosis
<i>COL22A1</i>
fibroblasts
TGF
Online Access:https://www.mdpi.com/2073-4425/10/2/75

Internet

https://www.mdpi.com/2073-4425/10/2/75

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