Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats.

Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats.

BACKGROUND: In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase inhibitor in the Notch signal pathway) treatment a...

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Main Authors: Li-Dong Zhao, Wei-Wei Guo, Chang Lin, Li-Xian Li, Jian-He Sun, Nan Wu, Li-Li Ren, Xin-Xin Li, Hui-Zhan Liu, Wie-Yen Young, Wei-Qiang Gao, Shi-Ming Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3197578?pdf=render

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http://europepmc.org/articles/PMC3197578?pdf=render

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