In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics

In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics

Drug resistance is a core issue in cancer chemotherapy. A known folate antagonist, methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme responsible for the catalysis of 7,8-dihydrofolate reduction to 5,6,7,8-tetrahydrofolate, in biosynthesis and cell proliferation. Structura...

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Bibliographic Details
Main Authors: Rabia Mukhtar Rana, Shailima Rampogu, Noman Bin Abid, Amir Zeb, Shraddha Parate, Gihwan Lee, Sanghwa Yoon, Yumi Kim, Donghwan Kim, Keun Woo Lee
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
methotrexate
Drug resistance
human dihydrofolate reductase
pharmacophore modeling
virtual screening
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/15/3510

Internet

https://www.mdpi.com/1420-3049/25/15/3510

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