Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia

Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia

Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO) bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO are known to modulate eryptosis in healthy red blood cells (RBCs); however, their role in SCA eryptosis and their impact on the gene...

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Bibliographic Details
Main Authors: Elie Nader, Marc Romana, Nicolas Guillot, Romain Fort, Emeric Stauffer, Nathalie Lemonne, Yohann Garnier, Sarah Chambers Skinner, Maryse Etienne-Julan, Mélanie Robert, Alexandra Gauthier, Giovanna Cannas, Sophie Antoine-Jonville, Benoît Tressières, Marie-Dominique Hardy-Dessources, Yves Bertrand, Cyril Martin, Céline Renoux, Philippe Joly, Marijke Grau, Philippe Connes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
sickle cell anemia
eryptosis
red blood cell microparticles
vascular dysfunction
endothelial cells
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.551441/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.551441/full

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