CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

Abstract Background Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechanisms that are not fully understood. The essential...

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Bibliographic Details
Main Authors: Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer & Metabolism
Subjects:
Coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4)
hypoxia
HIF-1α
mitochondria
respiratory chain
disulfide relay system
Online Access:http://link.springer.com/article/10.1186/s40170-019-0200-4

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http://link.springer.com/article/10.1186/s40170-019-0200-4

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