Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Summary: Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular or...

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Main Authors: Lu Wang, Daniel Hiler, Beisi Xu, Issam AlDiri, Xiang Chen, Xin Zhou, Lyra Griffiths, Marc Valentine, Abbas Shirinifard, András Sablauer, Suresh Thiagarajan, Marie-Elizabeth Barabas, Jiakun Zhang, Dianna Johnson, Sharon Frase, Michael A. Dyer
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301396

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http://www.sciencedirect.com/science/article/pii/S2211124718301396

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