Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Abstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two m...

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Bibliographic Details
Main Authors: Taku Saito, Sakae Tanaka
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Articular chondrocyte
Notch
NF-κB
Online Access:http://link.springer.com/article/10.1186/s13075-017-1296-y

Internet

http://link.springer.com/article/10.1186/s13075-017-1296-y

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