Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
Abstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two m...
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doaj-32838f2841ef444392c08f5245516a762020-11-25T02:43:09ZengBMCArthritis Research & Therapy1478-63622017-05-011911710.1186/s13075-017-1296-yMolecular mechanisms underlying osteoarthritis development: Notch and NF-κBTaku Saito0Sakae Tanaka1Graduate School of Medicine, The University of TokyoGraduate School of Medicine, The University of TokyoAbstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed.http://link.springer.com/article/10.1186/s13075-017-1296-yOsteoarthritisArticular chondrocyteNotchNF-κB |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taku Saito Sakae Tanaka |
spellingShingle |
Taku Saito Sakae Tanaka Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB Arthritis Research & Therapy Osteoarthritis Articular chondrocyte Notch NF-κB |
author_facet |
Taku Saito Sakae Tanaka |
author_sort |
Taku Saito |
title |
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB |
title_short |
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB |
title_full |
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB |
title_fullStr |
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB |
title_full_unstemmed |
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB |
title_sort |
molecular mechanisms underlying osteoarthritis development: notch and nf-κb |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2017-05-01 |
description |
Abstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed. |
topic |
Osteoarthritis Articular chondrocyte Notch NF-κB |
url |
http://link.springer.com/article/10.1186/s13075-017-1296-y |
work_keys_str_mv |
AT takusaito molecularmechanismsunderlyingosteoarthritisdevelopmentnotchandnfkb AT sakaetanaka molecularmechanismsunderlyingosteoarthritisdevelopmentnotchandnfkb |
_version_ |
1724771161801228288 |