Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Abstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two m...

Full description

Bibliographic Details
Main Authors:	Taku Saito, Sakae Tanaka
Format:	Article
Language:	English
Published:	BMC 2017-05-01
Series:	Arthritis Research & Therapy
Subjects:	Osteoarthritis Articular chondrocyte Notch NF-κB
Online Access:	http://link.springer.com/article/10.1186/s13075-017-1296-y

id	doaj-32838f2841ef444392c08f5245516a76
record_format	Article
spelling	doaj-32838f2841ef444392c08f5245516a762020-11-25T02:43:09ZengBMCArthritis Research & Therapy1478-63622017-05-011911710.1186/s13075-017-1296-yMolecular mechanisms underlying osteoarthritis development: Notch and NF-κBTaku Saito0Sakae Tanaka1Graduate School of Medicine, The University of TokyoGraduate School of Medicine, The University of TokyoAbstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed.http://link.springer.com/article/10.1186/s13075-017-1296-yOsteoarthritisArticular chondrocyteNotchNF-κB
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taku Saito Sakae Tanaka
spellingShingle	Taku Saito Sakae Tanaka Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB Arthritis Research & Therapy Osteoarthritis Articular chondrocyte Notch NF-κB
author_facet	Taku Saito Sakae Tanaka
author_sort	Taku Saito
title	Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
title_short	Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
title_full	Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
title_fullStr	Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
title_full_unstemmed	Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
title_sort	molecular mechanisms underlying osteoarthritis development: notch and nf-κb
publisher	BMC
series	Arthritis Research & Therapy
issn	1478-6362
publishDate	2017-05-01
description	Abstract Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed.
topic	Osteoarthritis Articular chondrocyte Notch NF-κB
url	http://link.springer.com/article/10.1186/s13075-017-1296-y
work_keys_str_mv	AT takusaito molecularmechanismsunderlyingosteoarthritisdevelopmentnotchandnfkb AT sakaetanaka molecularmechanismsunderlyingosteoarthritisdevelopmentnotchandnfkb
_version_	1724771161801228288

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Similar Items