HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes.

HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes.

Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can strongly influence the expression of genes and endogenous retroviral elements with concomitant dsRNA synthesis and massive transcription of LT...

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Bibliographic Details
Main Authors: Varvara Maksimova, Natalya Shalginskikh, Olga Vlasova, Olga Usalka, Anastasia Beizer, Polina Bugaeva, Dmitry Fedorov, Olga Lizogub, Ekaterina Lesovaya, Richard Katz, Gennady Belitsky, Kirill Kirsanov, Marianna Yakubovskaya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0252504

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https://doi.org/10.1371/journal.pone.0252504

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