Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Development of resistance to chemotherapy is a major obstacle in extending the survival of patients with cancer. Although originally defined as an immune checkpoint molecule, B7-H1 (also named as PD-L1 or CD274) was found to play a role in cancer chemoresistance; however, the underlying mechanism of...

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Bibliographic Details
Main Authors: Xiaosheng Wu, Yanli Li, Xin Liu, Chunhua Chen, Susan M. Harrington, Siyu Cao, Tiancheng Xie, Tu Pham, Aaron S. Mansfield, Yiyi Yan, Eugene D. Kwon, Liewei Wang, Kun Ling, Haidong Dong
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Oncology
Cancer research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018323442

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http://www.sciencedirect.com/science/article/pii/S2405844018323442

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