Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants.

Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants.

Tumor necrosis factor-alpha (TNF) binds to two receptors: TNFR1/p55-cytotoxic and TNFR2/p75-pro-survival. We have shown that tumor growth in p75 knockout (KO) mice was decreased more than 2-fold in Lewis lung carcinoma (LLCs). We hypothesized that selective blocking of TNFR2/p75 LLCs may sensitize t...

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Bibliographic Details
Main Authors: Sharath P Sasi, Sanggyu Bae, Jin Song, Aleksandr Perepletchikov, Douglas Schneider, Joseph Carrozza, Xinhua Yan, Raj Kishore, Heiko Enderling, David A Goukassian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963887?pdf=render

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http://europepmc.org/articles/PMC3963887?pdf=render

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