Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Abstract Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer’s Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to assess the LC integrity in AD (n = 37) and controls (n = 17). The LC‐I was decreased in AD regardless of typic...

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Bibliographic Details
Main Authors: Pauline Olivieri, Julien Lagarde, Stéphane Lehericy, Romain Valabrègue, Adeline Michel, Pierre Macé, Fabien Caillé, Philippe Gervais, Michel Bottlaender, Marie Sarazin
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.50818

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https://doi.org/10.1002/acn3.50818

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